Understanding Cell Structures in Inflammation and Bacterial Infections
The Role of Intermediate Filaments in Inflammation
This project explores how tiny structures inside our cells, called intermediate filaments, help control inflammation, especially during bacterial infections.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-11126722 on NIH RePORTER |
What this research studies
Our bodies have tiny structures inside cells, called intermediate filaments, which are important for how cells work and respond to threats. While we know they provide support, we are learning they also play a big role in many body processes, including inflammation. This project aims to discover exactly how these cell structures are controlled and how they contribute to the body's inflammatory response. We are particularly interested in their function within immune cells called neutrophils, which are crucial for fighting bacterial infections. By understanding these basic cellular mechanisms, we hope to find new ways to manage inflammation.
Who could benefit from this research
Good fit: This foundational research does not directly involve patients, but future studies stemming from this work might seek individuals with inflammatory conditions or bacterial infections.
Not a fit: Patients seeking immediate new treatments or direct clinical intervention would not find direct benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could lead to new insights into how inflammation is regulated, potentially opening doors for better treatments for conditions involving bacterial infections and uncontrolled inflammation.
How similar studies have performed: This project builds on the principal investigator's prior successful work investigating intermediate filament function during bacterial infection, using established screening approaches.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Russo, Brian — University of Colorado Denver
- Study coordinator: Russo, Brian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.