Understanding Cell Interactions in Inflamed Tissues
Reconstructing Cell-Cell Interactions in Diverse Inflammatory Environments
This project aims to understand how our immune cells, called neutrophils, react to different inflammatory signals, hoping to find new ways to help people with infections and autoimmune diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado NIH-funded |
| Lab location | 1 site (Boulder, UNITED STATES) |
| Project ID | NIH-11142542 on NIH RePORTER |
What this research studies
Our bodies' immune cells, called neutrophils, are crucial for fighting infections and healing, but sometimes they don't work correctly, leading to ongoing infections, tissue damage, or conditions like autoimmune diseases. This project uses advanced lab models with human cells to closely watch how neutrophils respond to various signals in inflamed tissues. By understanding these complex interactions, we hope to discover new targets to control neutrophil behavior. This could lead to better treatments for a range of conditions where neutrophils play a harmful role.
Who could benefit from this research
Good fit: Patients with autoimmune diseases or chronic infections where neutrophil dysfunction is suspected might eventually benefit from therapies developed from this fundamental understanding.
Not a fit: Patients whose conditions are not related to neutrophil function or inflammation may not directly benefit from this specific line of basic research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that better control neutrophil activity, potentially reducing inflammation and tissue damage in autoimmune diseases and improving the body's response to infections.
How similar studies have performed: This approach builds on existing knowledge of neutrophil biology but uses novel engineered platforms to gain a more detailed understanding of complex cell-cell interactions in inflammation.
Where this research is happening
Boulder, UNITED STATES
- University of Colorado — Boulder, United States (Active)
Researchers
- Principal investigator: Hind, Laurel Erin — University of Colorado
- Study coordinator: Hind, Laurel Erin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.