Understanding Cell Connections in Blood and Blood Vessels
Cell Adhesion and Signaling in Blood and Vascular Cells
This research explores how cells in our blood and blood vessels stick together and communicate, which is important for heart health.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-11123997 on NIH RePORTER |
What this research studies
Our bodies rely on cells to stick together and send signals, especially in our blood and blood vessels. This project focuses on specific proteins called integrins that act like "sticky hands" on these cells. We want to understand how these integrins are controlled by other molecules, like kindlins, talin, and paxillin, to ensure healthy blood flow. By studying these processes in different types of cells, including those from blood and vessel walls, we hope to uncover new ways to keep our cardiovascular system healthy.
Who could benefit from this research
Good fit: Patients with or at risk for atherosclerotic cardiovascular disease may eventually benefit from the knowledge gained from this fundamental research.
Not a fit: Patients seeking immediate new treatments or direct clinical intervention will not find it in this basic science project.
Why it matters
Potential benefit: This work could lead to a deeper understanding of how blood and vascular cells contribute to conditions like atherosclerotic cardiovascular disease, potentially paving the way for new treatments.
How similar studies have performed: This program builds upon existing knowledge of integrins and cell signaling, aiming to provide a more comprehensive understanding of their roles in vascular health.
Where this research is happening
Cleveland, United States
- Cleveland Clinic Lerner Com-Cwru — Cleveland, United States (Active)
Researchers
- Principal investigator: Qin, Jun — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Qin, Jun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.