Understanding brain differences in schizophrenia and related conditions
Official title: Neuroimaging Dimensions at the Extremes of the Schizophrenia Spectrum
Funded at University of California-Irvine · NIH-10928778 · Data updated 2026-11-12
This study is looking at how schizophrenia affects the brain and how things like medication and how long someone has had the condition can change what we see in brain scans, all to help find better ways to identify and treat people with schizophrenia.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project start | September 15, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $714,998 |
| NIH project number | 5R01MH134526-02 |
| Project ID | NIH-10928778 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with schizophrenia or those exhibiting subclinical psychotic traits.
✕Less likely to help
Patients with other mental health disorders unrelated to schizophrenia may not receive benefit from this research.
What this research studies
This research investigates the neurobiological underpinnings of schizophrenia, a severe mental health disorder, by utilizing advanced neuroimaging techniques. The study aims to identify brain abnormalities associated with schizophrenia and how factors like medication and disease duration affect these findings. By analyzing data from large-scale collaborative efforts, the research seeks to improve early identification and treatment strategies for individuals affected by this condition. Patients may undergo brain imaging to help researchers understand the relationship between brain structure and schizophrenia symptoms.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic methods and more effective treatments for schizophrenia, enhancing patient outcomes.
How similar studies have gone: Previous research has shown promising results in understanding brain abnormalities in schizophrenia through neuroimaging, indicating that this approach has potential for significant insights.
Where this research is happening
-
University of California-Irvine
Irvine, United States Active
Researchers
- Principal investigator: Van Erp, Theodorus G.m. — University of California-Irvine
- Study coordinator: Van Erp, Theodorus G.m.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.