Understanding brain connections in depression and anxiety
Official title: Multidimensional brain connectome features of depression and anxiety
Funded at Icahn School of Medicine at Mount Sinai · NIH-11000757 · Data updated 2026-11-12
This study is looking at how different parts of the brain talk to each other in people with depression and anxiety, using special MRI technology to create detailed maps, so we can better understand these conditions and find new ways to help.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | January 16, 2023 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $176,961 |
| NIH project number | 5K01MH131855-03 |
| Project ID | NIH-11000757 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with major depressive disorder or generalized anxiety disorder.
✕Less likely to help
Patients with other mental health conditions not related to depression or anxiety may not benefit from this research.
What this research studies
This research investigates how different regions of the brain communicate with each other in individuals suffering from depression and anxiety. By using advanced 7-Tesla MRI technology, the study aims to create detailed maps of brain connectivity, focusing on specific areas involved in emotion regulation. The researchers will compare these brain maps between healthy individuals and those diagnosed with major depressive disorder and generalized anxiety disorder. The goal is to identify unique brain network patterns that could serve as biomarkers for these conditions.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and targeted treatments for depression and anxiety.
How similar studies have gone: Previous research has shown promise in using advanced brain imaging techniques to understand mood and anxiety disorders, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Jacob, Yael — Icahn School of Medicine at Mount Sinai
- Study coordinator: Jacob, Yael
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.