Understanding brain changes in Alzheimer's disease
Official title: Causal and Event Based Modeling of Brain Alterations in ADRD
Funded at University of Southern California · NIH-11060786 · Data updated 2026-11-12
This study is looking at how Alzheimer's disease changes the brain and whether making lifestyle changes can help slow down these changes, with the goal of finding better ways to treat and support people with the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project start | January 1, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $622,401 |
| NIH project number | 1R01AG087513-01A1 |
| Project ID | NIH-11060786 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals aged 65 and older who are at risk for or currently experiencing symptoms of Alzheimer's disease.
✕Less likely to help
Patients under the age of 65 or those without any signs of cognitive decline may not benefit from this research.
What this research studies
This research investigates how brain alterations occur in Alzheimer's disease (AD) by using advanced neuroimaging techniques like MRI and PET scans. It aims to identify specific biomarkers that can indicate disease progression and explore how lifestyle modifications may influence these changes. By analyzing a wide range of brain data over time, the study seeks to develop causal models that can help in understanding the factors that may delay or prevent the onset of Alzheimer's. This approach is designed to provide insights that could lead to more effective treatment strategies for patients.
Why it matters
Potential benefit: If successful, this research could lead to earlier detection and better management of Alzheimer's disease, potentially improving the quality of life for patients.
How similar studies have gone: Previous research has shown promise in using neuroimaging and biomarkers to track Alzheimer's disease progression, indicating that this approach could yield valuable insights.
Where this research is happening
-
University of Southern California
Los Angeles, United States Active
Researchers
- Principal investigator: Jahanshad, Neda — University of Southern California
- Study coordinator: Jahanshad, Neda
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.