Understanding Brain Cancer Metabolism
Metabolic Regulation of Glioblastoma Epitranscriptomics
This project explores how changes in metabolism within brain cancer cells help them grow and resist treatment, aiming to find new ways to stop them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11105891 on NIH RePORTER |
What this research studies
Glioblastoma is a very aggressive brain cancer, and current treatments often don't work well because of special cells called glioblastoma stem cells (GSCs). These GSCs are tough to treat and can make the cancer come back. Our team is looking at how these GSCs use energy and nutrients differently, specifically focusing on how their metabolism affects their ability to survive and resist therapies. By understanding these unique metabolic pathways, we hope to discover new targets for medicines that could specifically weaken and eliminate these resistant cancer cells.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients but focuses on understanding glioblastoma, which affects adults diagnosed with brain cancer.
Not a fit: Patients without glioblastoma or those seeking immediate clinical treatment may not directly benefit from this early-stage laboratory research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that specifically target glioblastoma stem cells, potentially improving outcomes for patients with this aggressive brain cancer.
How similar studies have performed: Previous work has shown that targeting metabolic pathways can reduce glioblastoma stem cell growth, suggesting this approach holds promise.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Agnihotri, Sameer — University of Pittsburgh at Pittsburgh
- Study coordinator: Agnihotri, Sameer
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.