Understanding and treating chronic graft-versus-host disease after blood cell transplants
Biostatistics and Data Management
This study is looking to help people who have had a stem cell transplant for blood cancer by learning more about a common complication called chronic graft-versus-host disease (cGVHD) and testing new treatments to improve their health, especially for lung issues related to cGVHD.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dana-Farber Cancer Inst NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10914137 on NIH RePORTER |
What this research studies
This research focuses on improving outcomes for patients who undergo allogeneic hematopoietic cell transplantation, a treatment for blood cancers. It aims to better understand chronic graft-versus-host disease (cGVHD), a complication that can arise after the transplant, by investigating the immune responses and mechanisms that lead to this condition. The research includes identifying immune networks in patients, developing new therapies for lung complications associated with cGVHD, and conducting a clinical trial to test a specific treatment. By analyzing both clinical data and animal models, the project seeks to uncover new therapeutic strategies to enhance patient care.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients who have received allogeneic hematopoietic cell transplants and are at risk of developing chronic graft-versus-host disease.
Not a fit: Patients who have not undergone allogeneic hematopoietic cell transplantation or those with other unrelated health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for chronic graft-versus-host disease, enhancing the quality of life and survival rates for patients undergoing blood cell transplants.
How similar studies have performed: Previous research has shown promise in understanding and treating graft-versus-host disease, indicating that this approach may build on existing knowledge and therapies.
Where this research is happening
Boston, United States
- Dana-Farber Cancer Inst — Boston, United States (Active)
Researchers
- Principal investigator: Kim, Haesook T — Dana-Farber Cancer Inst
- Study coordinator: Kim, Haesook T
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.