Understanding and restoring awareness of hypoglycemia in type 1 diabetes
Official title: Elucidating the heterogeneity of impaired awareness of hypoglycaemia in type 1 diabetes
Funded at University of Leicester · NIH-11538452 · Data updated 2026-11-12
A study in people with type 1 diabetes and impaired awareness of hypoglycemia to see how advanced insulin delivery technology can help restore the body's warning signals.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Leicester NIH-funded |
| Lab location | 1 site (Leicester, United Kingdom) |
| Project start | September 25, 2022 |
| Project end | December 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $67,483 |
| NIH project number | 3U01DK135128-04S1 |
| Project ID | NIH-11538452 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with type 1 diabetes and impaired awareness of hypoglycemia.
✕Less likely to help
Patients without impaired awareness or not using hybrid closed-loop systems may have limited direct benefit.
What this research studies
This project will follow people with type 1 diabetes who have impaired awareness of low blood sugar to understand how the body’s responses change when they use advanced hybrid closed-loop insulin delivery. It will study physiological reactions during controlled low-blood-sugar situations and track how switching to newer insulin technology affects these responses over time. Researchers will develop and validate better tools to measure changes in hypoglycemia awareness beyond current screening methods. The work aims to identify factors that help restore awareness and improve safety for patients at risk of severe hypoglycemia.
Why it matters
Potential benefit: If successful, patients could experience better recognition of low blood sugar and fewer dangerous events while using advanced insulin systems.
How similar studies have gone: Previous research shows mixed results; this project addresses gaps with newer CGM-era tools.
Where this research is happening
-
University of Leicester
Leicester, United Kingdom Active
Researchers
- Principal investigator: Choudhary, Pratik — University of Leicester
- Study coordinator: Choudhary, Pratik
Related research
Other NIH-funded projects on the same topics.
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Technological and Educational Approaches to Restore Hypoglycemia Awareness in Type 1 Diabetes
A two-arm study in adults with type 1 diabetes tests whether high-tech glucose control plus education or targeted training can help people regain awareness of low blood sugar.
-
Techniques for restoring awareness of low blood sugar in adults with type 1 diabetes
A randomized trial compares different approaches to help adults with type 1 diabetes recognize when their blood sugar is dipping so they can act quickly.
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Treating impaired hypoglycemia awareness in type 1 diabetes with targeted education and technology
This study tests two treatment approaches to help adults with type 1 diabetes who often don’t realize their blood sugar is getting too low, using a mix of technology and education in two large groups.
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Helping people with type 1 diabetes regain awareness of dangerous lows
A UK study tests two different approaches to help adults with type 1 diabetes recognize and respond to low blood sugar by comparing a high-tech insulin system with targeted education.
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How the pancreas environment affects insulin-producing cells in type 1 diabetes
Researchers are studying how the surrounding tissue of the pancreas and its proteins influence insulin-producing cells in people with type 1 diabetes.
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Understanding how hypoglycemia awareness changes in adults with type 1 diabetes and how automated insulin delivery and exercise might help restore it
This study will look at adults with type 1 diabetes to see how their awareness of low blood sugar evolves over time and whether automated insulin delivery and high-intensity exercise can help restore that awareness.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.