Understanding and Reducing Inflammation in Severe COVID-19
Role and Mitigation of Inflammasomes and Inflammation During COVID-19
['FUNDING_R01'] · UNIV OF NORTH CAROLINA CHAPEL HILL · NIH-11123319
This project looks at how inflammation causes severe lung problems in COVID-19 patients and explores ways to lessen its effects.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF NORTH CAROLINA CHAPEL HILL (nih funded) |
| Locations | 1 site (CHAPEL HILL, UNITED STATES) |
| Trial ID | NIH-11123319 on ClinicalTrials.gov |
What this research studies
Many people with severe COVID-19 develop acute respiratory distress syndrome (ARDS), a dangerous lung condition caused by an overactive immune response called a "cytokine storm." This project aims to understand the specific immune pathways, called inflammasomes, that trigger this severe inflammation and cell damage. By learning more about how these pathways work, we hope to find new ways to stop or reduce the harmful inflammation in patients with severe COVID-19. This knowledge could lead to better treatments for those struggling with ARDS.
Who could benefit from this research
Good fit: This foundational work is for patients who have experienced or are at risk of developing acute respiratory distress syndrome due to COVID-19 infection.
Not a fit: Patients with mild COVID-19 symptoms or those without respiratory complications may not directly benefit from this specific research focus.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that reduce severe lung damage and improve outcomes for patients with COVID-19-related ARDS.
How similar studies have performed: Other clinical efforts have shown some success with IL-1 inhibitors in COVID-19 patients, suggesting that targeting inflammatory pathways is a promising approach.
Where this research is happening
CHAPEL HILL, UNITED STATES
- UNIV OF NORTH CAROLINA CHAPEL HILL — CHAPEL HILL, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TING, JENNY P — UNIV OF NORTH CAROLINA CHAPEL HILL
- Study coordinator: TING, JENNY P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acute Respiratory Distress Syndrome, Adult Respiratory Distress Syndrome