Understanding and reducing heart disease risk despite treatment
Official title: Targeting Residual ASCVD Risk by Integrating Genetics and Clinical Data
Funded at Vanderbilt University Medical Center · NIH-10780351 · Data updated 2026-11-12
This study is looking into why some people still have heart attacks and strokes even when they're taking medicine to lower cholesterol and blood pressure, and it wants to find out if genetics play a role, so if you're interested in helping us learn more about this and possibly improve treatments, we’d love for you to join us by sharing some health information and genetic samples.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | July 15, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $874,792 |
| NIH project number | 1R01HL171809-01 |
| Project ID | NIH-10780351 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced cardiovascular events despite being treated for high cholesterol or blood pressure.
✕Less likely to help
Patients who have not been diagnosed with cardiovascular disease or are not currently on treatment for cholesterol or blood pressure may not benefit from this research.
What this research studies
This research investigates why some patients continue to experience heart attacks and strokes even while receiving treatment to lower cholesterol and blood pressure. It aims to uncover the genetic factors contributing to this ongoing risk and identify individuals who are at a higher risk for these events. By analyzing genetic data and electronic health records, the study seeks to develop better predictive models and explore new treatment options that could help mitigate this risk. Patients may be asked to participate by providing genetic samples and health information.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing heart attacks and strokes in patients already on treatment.
How similar studies have gone: Previous research has shown promise in understanding genetic factors related to cardiovascular disease, indicating that this approach could yield valuable insights.
Where this research is happening
-
Vanderbilt University Medical Center
Nashville, United States Active
Researchers
- Principal investigator: Wei, Wei-Qi — Vanderbilt University Medical Center
- Study coordinator: Wei, Wei-Qi
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.