Understanding and improving motor recovery after stroke
Official title: Neurophysiological Basis for Enhancing Motor Recovery After Stroke
Funded at Veterans Affairs Med Ctr San Francisco · NIH-11357333 · Data updated 2026-11-12
A study exploring how abnormal arm muscle patterns develop after stroke and testing ways to reduce them to improve movement.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Affairs Med Ctr San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | October 1, 2015 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| NIH project number | 5I01RX001640-12 |
| Project ID | NIH-11357333 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients who have had a stroke and experience upper-limb motor deficits.
✕Less likely to help
Direct patient benefit is not guaranteed; the study is conducted in animals and may not translate immediately to humans.
What this research studies
This project uses a mouse model of stroke to map how specific brain pathways change over time and how these changes lead to abnormal arm movements. Researchers will label and track corticoreticular pathways and test two interventions aimed at reducing flexor tone during reaching and grasping. If successful, the work could point to new strategies to help stroke survivors regain independent arm function.
Why it matters
Potential benefit: If successful, this research could lead to new approaches to lessen motor disability after stroke and improve daily function for patients.
How similar studies have gone: Previous work in stroke models shows pathway changes and motor pattern alterations; this study proceeds with targeted, pathway-specific tracking and interventions.
Where this research is happening
-
Veterans Affairs Med Ctr San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Ganguly, Karunesh — Veterans Affairs Med Ctr San Francisco
- Study coordinator: Ganguly, Karunesh
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.