Understanding ANA+ and ANA- B cells in people with SLE and healthy individuals
Official title: Principal Project-Characterization of ANA+ and ANA-B cells in individuals with SLE and healthy subjects
Funded at Feinstein Institute for Medical Research · NIH-11520866 · Data updated 2026-11-12
Researchers will study how different B cell types behave in lupus patients compared with healthy people to identify clues for better treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Feinstein Institute for Medical Research NIH-funded |
| Lab location | 1 site (Manhasset, United States) |
| Project start | May 1, 2019 |
| Project end | April 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $335,000 |
| NIH project number | 5U19AI144306-08 |
| Project ID | NIH-11520866 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with SLE and healthy volunteers who consent to provide blood samples for immune-cell analyses.
✕Less likely to help
Individuals without lupus may participate for research purposes but are unlikely to benefit directly.
What this research studies
This project looks at how B cells and related immune cells behave before lupus flares so doctors can tailor treatments. It compares people with systemic lupus erythematosus (SLE) to healthy volunteers to understand why autoantibodies arise and drive disease. By examining antigen presentation and antibody-secreting cells, the study aims to find markers that predict flares and guide future trials. The work is designed to inform patient stratification for therapies and identify new targets to improve remission rates and quality of life.
Why it matters
Potential benefit: Better understanding of immune triggers in lupus could lead to more precise treatments and fewer disease flares for patients.
How similar studies have gone: Prior research has shown that B cell dynamics and autoantibody production relate to lupus activity, supporting this approach as a promising avenue.
Where this research is happening
-
Feinstein Institute for Medical Research
Manhasset, United States Active
Researchers
- Principal investigator: Diamond, Betty — Feinstein Institute for Medical Research
- Study coordinator: Diamond, Betty
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.