Understanding Amyloid Fibril Formation in Diseases Using Space-Based Simulations
Official title: Probing Amyloid Fibril Self-Assembly with Network Hamiltonian Simulations in Explicit Space
Funded at San Jose State University · NIH-11376910 · Data updated 2026-11-12
Researchers will use advanced computer models to study how tiny protein fibers that cause diseases like Alzheimer’s and type 2 diabetes start forming.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | San Jose State University NIH-funded |
| Lab location | 1 site (San Jose, United States) |
| Project start | August 16, 2023 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $183,125 |
| NIH project number | 5R16GM150706-04 |
| Project ID | NIH-11376910 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable to a specific patient group in this grant; results may ultimately benefit people with Alzheimer's disease, type 2 diabetes, and related amyloid disorders.
✕Less likely to help
No direct patient participation is described in this grant.
What this research studies
This project uses a novel simulation approach to model how amyloid fibrils begin to form in human diseases. By coupling different representations of protein ensembles in explicit space, it aims to reveal how primary nucleation starts and propagates. The work could help identify new points to intervene in disease processes, potentially guiding future therapies. The study is focused on tasks that translate theoretical ideas into understanding disease mechanisms at the molecular level.
Why it matters
Potential benefit: If successful, the work could inform new strategies to prevent or slow amyloid-related diseases by targeting early stages of fibril formation.
How similar studies have gone: Past work has shown that similar modeling approaches can capture key features of fibril formation, supporting the potential usefulness of this method.
Where this research is happening
-
San Jose State University
San Jose, United States Active
Researchers
- Principal investigator: Grazioli, Gianmarc — San Jose State University
- Study coordinator: Grazioli, Gianmarc
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.