Understanding Alzheimer's Disease through Genetic and Tissue Information
Integrative multivariate association and genomic analyses
['FUNDING_R01'] · UNIVERSITY OF CHICAGO · NIH-11145193
This work aims to better understand Alzheimer's disease by looking closely at how our genes and other factors affect brain health.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CHICAGO (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-11145193 on ClinicalTrials.gov |
What this research studies
Our bodies hold a lot of information in our tissues, including details about our genes and how they are turned on or off. This project uses existing information from hundreds of people, specifically looking at brain and other tissue samples, to find connections between genetic variations and how genes behave. We are developing new computer methods to combine these different types of information, like genetic markers and gene activity, to get a clearer picture of what contributes to Alzheimer's disease. By doing this, we hope to uncover new insights into the disease's causes.
Who could benefit from this research
Good fit: This research is most relevant to patients with Alzheimer's disease, those at risk, or their families who are interested in the underlying genetic causes of the condition.
Not a fit: Patients without Alzheimer's disease or those not interested in genetic and biological research into the disease may not find direct benefit from this particular study.
Why it matters
Potential benefit: If successful, this work could lead to a deeper understanding of the genetic and biological roots of Alzheimer's disease, potentially paving the way for new ways to prevent or treat it.
How similar studies have performed: This project builds upon existing methods for analyzing genetic data, aiming to improve and integrate them for a more comprehensive understanding of complex diseases.
Where this research is happening
CHICAGO, UNITED STATES
- UNIVERSITY OF CHICAGO — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHEN, LIN — UNIVERSITY OF CHICAGO
- Study coordinator: CHEN, LIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease, Brain Diseases, Brain Disorders