Understanding aging immune cells in inflammatory bowel disease
Official title: Aging lymphocytes: senescence programs in lymphocytes relevant to human inflammatory bowel disease
Funded at Mayo Clinic Arizona · NIH-11198835 · Data updated 2026-11-12
This study is looking at how getting older affects certain immune cells in people with Crohn's disease, with the goal of finding ways to help these cells work better and improve treatments for managing inflammation in the gut.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Arizona NIH-funded |
| Lab location | 1 site (Scottsdale, United States) |
| Project start | January 4, 2023 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $163,614 |
| NIH project number | 7K08DK134759-03 |
| Project ID | NIH-11198835 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Crohn's disease who are experiencing ongoing intestinal inflammation.
✕Less likely to help
Patients with inflammatory bowel disease who are in remission or do not have Crohn's disease may not benefit from this research.
What this research studies
This research investigates how aging affects specific immune cells, known as FOXP3+ T regulatory cells, in patients with Crohn's disease. It aims to uncover the mechanisms that lead to the dysfunction of these cells, which are crucial for controlling inflammation in the gut. By analyzing these cells at a single-cell level, the study seeks to identify potential therapeutic targets to restore their normal function, potentially leading to new treatments for inflammatory bowel disease. The research will also explore advanced therapies that could enhance the effectiveness of these immune cells in managing the disease.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve the regulation of inflammation in patients with inflammatory bowel disease.
How similar studies have gone: Previous research has shown promise in targeting immune cell dysfunction in other autoimmune conditions, suggesting potential for success in this novel approach.
Where this research is happening
-
Mayo Clinic Arizona
Scottsdale, United States Active
Researchers
- Principal investigator: Gonzalez Salgado, Michelle M — Mayo Clinic Arizona
- Study coordinator: Gonzalez Salgado, Michelle M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.