Triggers of thrombotic microangiopathy after stem cell transplant
Initiators of thrombotic microangiopathy
This project looks for viruses and other biological triggers that cause thrombotic microangiopathy in children after hematopoietic (bone marrow) transplant.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-11249547 on NIH RePORTER |
What this research studies
Thrombotic microangiopathy (TMA) is a serious complication that affects about one in five children after transplant and can damage multiple organs. The team will examine blood samples and use protein and genetic tests to look for changes—such as higher levels of PI4K—and for viruses like BK polyomavirus that may appear after transplant. They will sequence viral samples, compare findings to clinical TMA outcomes, and build on past work showing links between immune system pathways (complement and interferon) and TMA. Their goal is to connect specific triggers to the TMA that some children develop so treatments can be better targeted.
Who could benefit from this research
Good fit: Children who have recently received a hematopoietic stem cell transplant and who are being monitored for post-transplant complications, especially those with or at risk for TMA or BK polyomavirus in the blood, are the most likely candidates.
Not a fit: Adults, people without transplant-related TMA, or patients whose TMA is caused by unrelated factors may not directly benefit from this pediatric transplant-focused research.
Why it matters
Potential benefit: If successful, this work could help identify viral or molecular triggers so doctors can prevent or treat TMA earlier and improve survival and organ outcomes for children after transplant.
How similar studies have performed: Previous work from this group showed that blocking complement improved survival in many children with TMA, but linking specific viral triggers like BK polyomavirus is a newer area of study.
Where this research is happening
Cincinnati, United States
- Cincinnati Childrens Hosp Med Ctr — Cincinnati, United States (Active)
Researchers
- Principal investigator: Jodele, Sonata — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Jodele, Sonata
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.