Translation Accelerator Core for rapid antiviral development
Official title: Translation Accelerator Core
Funded at Stanford University · NIH-11587811 · Data updated 2026-11-12
A core at Stanford helps turn promising antiviral ideas for COVID-19 and other RNA viruses into real drugs, with industry-style guidance and preclinical work.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | May 16, 2022 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $6,139,104 |
| NIH project number | 4U19AI171421-02 |
| Project ID | NIH-11587811 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with COVID-19 or other RNA virus infections who might benefit from future antiviral therapies could be involved in later clinical development phases.
✕Less likely to help
Patients who are not eligible for future trials or do not develop or receive investigational antivirals may not benefit.
What this research studies
This grant supports a Translational Accelerator Core that brings in industry-level experts to push antiviral projects toward clinical testing. It covers lead discovery, optimization, IND-enabling studies, and regulatory planning, using virtual screening, computational chemistry, and lab characterization. The aim is to accelerate safe, effective outpatient antivirals for SARS-CoV-2 and other RNA viruses, with a focus on efficiency and rigorous development. Researchers and clinicians collaborating with the AViDD Center will receive structured support to advance promising compounds toward potential therapies.
Why it matters
Potential benefit: This could shorten the path from promising antiviral compounds to approved therapies for COVID-19 and related viruses.
How similar studies have gone: Previous translational cores have successfully advanced antiviral candidates toward clinical testing, though each compound's path remains unique.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Grimes, Kevin V — Stanford University
- Study coordinator: Grimes, Kevin V
Related research
Other NIH-funded projects on the same topics.
-
Multimodal AI to predict CAR-T patient response and guide safer, smarter cell design
A Stanford team is building AI tools that use patient and CAR-T cell data to predict how well a CAR-T therapy will work and what design changes might boost effectiveness and safety for people with cancer.
-
Community-driven model to reduce overdose deaths through smarter resource use
A Stanford-led project uses a data-driven model to help counties pick the best ways to prevent opioid and stimulant overdoses and save lives.
-
Center for Dissemination and Implementation at Stanford: Research Core
A Stanford-based program is advancing how evidence-based addiction treatments are implemented across settings to help people with substance use disorders receive better care.
-
Center for Dissemination and Implementation At Stanford (C-DIAS)
A center-based program at Stanford aims to speed people who need addiction treatments to get evidence-based care.
-
Mitochondrial structure and neuron health in Alzheimer's and ALS
This grant studies how mitochondrial cristae structure in neurons is controlled and how its disruption may contribute to diseases like Alzheimer's and ALS.
-
Pediatric EMS seizures: simpler age-based midazolam dosing
A nationwide trial at EMS agencies tests whether using fixed, age-based dosing of midazolam for seizures in children improves treatment speed and safety.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.