Transforming blood vessel cells into blood stem cells
Reprogramming Gene Regulatory Networks to a Hematopoietic Stem Cell State
['FUNDING_R01'] · UNIVERSITY OF ILLINOIS AT CHICAGO · NIH-10863810
This study is exploring a way to turn cells that line our blood vessels into blood-making stem cells, which could help us learn more about producing blood cells and finding new treatments for blood-related illnesses.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ILLINOIS AT CHICAGO (nih funded) |
| Locations | 1 site (Chicago, UNITED STATES) |
| Trial ID | NIH-10863810 on ClinicalTrials.gov |
What this research studies
This research investigates how to convert endothelial cells, which line blood vessels, into hematopoietic stem cells (HSCs) that can produce blood cells. By using specific reprogramming factors, the study aims to understand the genetic changes that enable this transformation. The approach involves advanced techniques like single-cell profiling to analyze the molecular mechanisms at play during the reprogramming process. This could provide new insights into blood cell production and potential therapies for blood-related diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with blood disorders or those requiring hematopoietic stem cell transplantation.
Not a fit: Patients with conditions unrelated to blood cell production or those who do not require stem cell therapies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new methods for generating blood stem cells, improving treatment options for patients needing blood cell transplants.
How similar studies have performed: Other research has shown promise in reprogramming cells for therapeutic purposes, indicating that this approach could be viable.
Where this research is happening
Chicago, UNITED STATES
- UNIVERSITY OF ILLINOIS AT CHICAGO — Chicago, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHRONIS, KONSTANTINOS — UNIVERSITY OF ILLINOIS AT CHICAGO
- Study coordinator: CHRONIS, KONSTANTINOS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autoimmune Diseases