Transcriptomic changes in endometriosis development (early lesions)
Official title: Transcriptomic Changes during early endometriotic lesion development
Funded at Henry Ford Health + Michigan State University Health Sciences · NIH-11415199 · Data updated 2026-11-12
This grant studies how gene activity changes in early endometriotic lesions, aiming to understand better why endometriosis develops and how it might be detected earlier.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Henry Ford Health + Michigan State University Health Sciences NIH-funded |
| Lab location | 1 site (East Lansing, United States) |
| Project start | September 12, 2025 |
| Project end | August 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $683,232 |
| NIH project number | 5R01HD116742-02 |
| Project ID | NIH-11415199 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with or suspected of endometriosis, including teens and adults, who may benefit from earlier diagnosis or new treatment options.
✕Less likely to help
People without endometriosis or without a lesion-related diagnosis may not directly benefit.
What this research studies
Endometriosis causes chronic pelvic pain and can affect fertility. Researchers will use human tissue and animal models to map single-cell and spatial gene expression in early lesion development, linking what happens at the cellular level to disease progression. The study builds on a baboon model to compare with human tissues and seeks to identify non-invasive signals and potential non-hormonal treatment avenues. Findings could lead to earlier diagnosis and targeted therapies for adolescents and adults affected by endometriosis.
Why it matters
Potential benefit: If successful, this work could enable earlier diagnosis and pave the way for safer, non-hormonal treatments that improve quality of life.
How similar studies have gone: Prior work using baboon models has aligned with human lesion biology, supporting the approach but human translation remains ongoing.
Where this research is happening
-
Henry Ford Health + Michigan State University Health Sciences
East Lansing, United States Active
Researchers
- Principal investigator: Burns, Gregory Willis — Henry Ford Health + Michigan State University Health Sciences
- Study coordinator: Burns, Gregory Willis
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.