Tools to map how respiratory infections interact with human lung cells
CORE 2: Technology Core
This project builds advanced lab tools to map how bacteria and viruses affect human lung cells to help people with respiratory infections.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11088226 on NIH RePORTER |
What this research studies
The team develops and shares proteomics, genetic screening, and 3D cell culture technologies to identify how pathogens interact with human cells. They map protein-protein interactions, measure protein and post-translational modification changes, and run genetic screens to find host factors that control infection. Structural biology will visualize key host-pathogen complexes at atomic detail, and clinical patient data will be integrated to link lab findings to disease severity. The Technology Core provides the infrastructure and expertise to support researchers across the Host Pathogen Map Initiative.
Who could benefit from this research
Good fit: People with bacterial or other respiratory infections, or those able to donate lung-related samples, would be the most relevant candidates to contribute specimens or join related studies.
Not a fit: People without respiratory or lung infections and those seeking immediate personal clinical therapy are unlikely to receive direct benefit from this core technology work.
Why it matters
Potential benefit: Could point to new drug targets and biomarkers that improve treatment and predict outcomes for respiratory infections.
How similar studies have performed: Similar systems-biology and proteomics approaches have revealed host factors for infections like influenza and COVID-19, though combining 3D cultures with structural and clinical integration is relatively novel.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Swaney, Danielle L — University of California, San Francisco
- Study coordinator: Swaney, Danielle L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.