Tissue-resident memory CD8+ T cell growth: how these frontline cells multiply in tissues
Official title: Cellular and molecular regulation of tissue-resident memory CD8+ T cell proliferation
Funded at Versiti Blood Health, INC. · NIH-11435861 · Data updated 2026-11-12
Aims to understand how tissue-resident memory CD8+ T cells grow and renew themselves inside body tissues to better fight infections and cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Versiti Blood Health, INC. NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project start | September 1, 2026 |
| Project end | August 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $510,000 |
| NIH project number | 1DP2AI200992-01 |
| Project ID | NIH-11435861 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals whose tissues could be studied for TRM biology, typically through collaboration with patients undergoing medical procedures or tissue donations.
✕Less likely to help
Healthy individuals or those not contributing tissue samples may not benefit directly.
What this research studies
This project looks at specialized immune cells that stay in tissues after infection and may keep dividing locally. By studying their cellular and molecular signals, researchers want to uncover how TRM cells proliferate and maintain their population in tissues over years. The goal is to identify new targets that could be used to boost protective immunity where pathogens or tumors reappear. The work uses advanced lab studies to map cell states and division patterns, with potential implications for therapies that enhance tissue-specific immune responses.
Why it matters
Potential benefit: If successful, this research could lead to new ways to strengthen tissue-specific immune defense against infections and cancer.
How similar studies have gone: Previous work shows TRM can protect against local infections and cancers, but how they proliferate in tissues remains incompletely understood.
Where this research is happening
-
Versiti Blood Health, INC.
Milwaukee, United States Active
Researchers
- Principal investigator: Jarjour, Nicholas N — Versiti Blood Health, INC.
- Study coordinator: Jarjour, Nicholas N
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.