Understanding how TFPI-alpha blocks blood clotting in adults
Official title: Characterization of an isoform specific anticoagulant function of TFPI-alpha
Funded at Versiti Blood Health, INC. · NIH-11378320 · Data updated 2026-11-12
This NIH grant studies how a specific protein fragment called TFPI-alpha helps prevent blood clots in adults, aiming to understand its interactions with factors that start and propagate clotting.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Versiti Blood Health, INC. NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project start | August 1, 2002 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $720,653 |
| NIH project number | 5R01HL068835-19 |
| Project ID | NIH-11378320 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with or at risk for coagulation disorders related to TFPI-alpha, FV variants, or coagulation pathway abnormalities, including those with FV Leiden.
✕Less likely to help
People without coagulation disorders or those not influenced by TFPI-alpha pathways may not benefit directly.
What this research studies
If this research succeeds, it could clarify how TFPI-alpha interacts with FV/FVa to inhibit prothrombinase, a key step in clot formation. The project builds on biochemical studies and uses human-related models to explore how this interaction affects hemostasis and thrombosis. Results could illuminate why certain FV variants are linked to bleeding or clotting disorders and how TFPI-alpha contributes to embryonic development and vascular biology. The work may involve experiments with human components and relevant animal models to map the mechanism in detail.
Why it matters
Potential benefit: Better understanding of clotting control could lead to new targets or strategies to prevent bleeding or excessive clotting in patients.
How similar studies have gone: Previous studies have shown important roles for TFPI-alpha and FV interactions in coagulation, with some findings supported by animal models and human data.
Where this research is happening
-
Versiti Blood Health, INC.
Milwaukee, United States Active
Researchers
- Principal investigator: Mast, Alan E — Versiti Blood Health, INC.
- Study coordinator: Mast, Alan E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.