Tip60 acetyltransferase: unlocking heart regeneration after a heart attack
Official title: Role of Tip60 Acetyltransferase in Cardiac Regeneration and Repair
Funded at Medical College of Wisconsin · NIH-11447457 · Data updated 2026-11-12
Aims to understand how Tip60 enzyme controls heart cell survival and regeneration after a heart attack, with the goal of helping damaged hearts repair themselves.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project start | August 10, 2026 |
| Project end | April 30, 2030 |
| Funding year | 2026 |
| Award (this year) | $610,494 |
| NIH project number | 1R01HL182878-01A1 |
| Project ID | NIH-11447457 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with a history of ischemic heart disease or recent myocardial infarction may benefit from therapies developed from this work.
✕Less likely to help
Individuals without heart disease or those not related to myocardial injury are unlikely to benefit.
What this research studies
This project explores how Tip60, an enzyme that adds acetyl groups to proteins, influences whether heart cells survive after a heart attack and whether they can re-enter the cell cycle to repair damage. Researchers will study Tip60 isoforms and their roles in cardiomyocyte maturation and regeneration, using human-relevant models to identify strategies that shift balance toward healing. The work could lead to new approaches that preserve heart muscle and promote repair after ischemic injury. Findings could guide future therapies that help patients recover cardiac function after MI.
Why it matters
Potential benefit: If successful, this research could pave the way for therapies that enhance heart muscle regeneration and reduce scarring after a heart attack.
How similar studies have gone: Preclinical data suggest that targeting Tip60 pathways can influence cardiomyocyte survival and regeneration, with promising translation potential.
Where this research is happening
-
Medical College of Wisconsin
Milwaukee, United States Active
Researchers
- Principal investigator: Auchampach, John a — Medical College of Wisconsin
- Study coordinator: Auchampach, John a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.