Tiny RNA Changes in Brain Cancer
The role of small RNA modifications in glioma
['FUNDING_OTHER'] · UNIVERSITY OF ALABAMA AT BIRMINGHAM · NIH-11110368
This research explores how tiny changes in small RNAs, especially tRFs, might influence the growth and behavior of brain cancers like glioma.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ALABAMA AT BIRMINGHAM (nih funded) |
| Locations | 1 site (BIRMINGHAM, UNITED STATES) |
| Trial ID | NIH-11110368 on ClinicalTrials.gov |
What this research studies
Our bodies have tiny molecules called small RNAs that help control how our cells work. This project looks at how small changes to these RNAs, particularly a type called tRFs, might play a role in aggressive brain cancers like glioma. We've already seen signs that these changes are present in glioma cells and patients. The goal is to understand exactly how these modified tRFs affect cancer growth and behavior. This understanding could open doors for new ways to fight these aggressive brain tumors.
Who could benefit from this research
Good fit: This foundational work aims to understand brain cancer at a molecular level, which could eventually benefit patients diagnosed with glioma or glioblastoma.
Not a fit: Patients without a diagnosis of glioma or glioblastoma would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to understand and potentially treat aggressive brain cancers like glioma.
How similar studies have performed: While some evidence suggests small RNA modifications are important, this project explores a relatively new area regarding their specific role in glioma, building on promising preliminary findings.
Where this research is happening
BIRMINGHAM, UNITED STATES
- UNIVERSITY OF ALABAMA AT BIRMINGHAM — BIRMINGHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SU, ZHANGLI — UNIVERSITY OF ALABAMA AT BIRMINGHAM
- Study coordinator: SU, ZHANGLI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Brain Cancer