The role of mitochondrial DNA in chronic stress and inflammation
Mitochondrial DNA, chronic stress, and inflammation
This study looks at how long-term stress can harm tiny energy factories in our cells, called mitochondria, and cause inflammation, which might be linked to mental health problems, and it aims to find ways to help improve mental well-being for those affected.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10690702 on NIH RePORTER |
What this research studies
This research investigates how chronic stress affects mitochondrial function and inflammation, which may contribute to psychiatric disorders. It explores the mechanisms by which damaged mitochondria can lead to increased inflammation and how this process may be linked to mental health issues. The study involves both animal models and human data to understand the relationship between stress, mitochondrial dysfunction, and inflammatory responses. By examining the role of mitochondrial DNA in these processes, the research aims to identify potential therapeutic targets for improving mental health outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing chronic stress or diagnosed with psychiatric disorders related to stress.
Not a fit: Patients with acute stress responses or those not experiencing any psychiatric symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for psychiatric disorders linked to chronic stress and inflammation.
How similar studies have performed: Previous research has shown promising results in understanding the link between mitochondrial dysfunction and inflammation in various conditions, suggesting that this approach may yield valuable insights.
Where this research is happening
Houston, United States
- University of Texas Hlth Sci Ctr Houston — Houston, United States (Active)
Researchers
- Principal investigator: Pillai, Anilkumar — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Pillai, Anilkumar
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.