Testing how immune cells interact with blood vessels
Official title: High-throughput nanoIEA-based Assay for Screening Immune Cell-Vascular Interactions
Funded at Cornell University · NIH-10830332 · Data updated 2026-11-12
This study is looking at how immune cells and blood vessels work together during infections and inflammation, and it aims to create a new test to better understand these interactions, which could help us learn more about how problems with blood vessels might lead to autoimmune diseases and ongoing inflammation.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cornell University NIH-funded |
| Lab location | 1 site (Ithaca, United States) |
| Project start | April 19, 2023 |
| Project end | March 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $237,913 |
| NIH project number | 5R21AI168886-02 |
| Project ID | NIH-10830332 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from autoimmune diseases or chronic inflammatory conditions.
✕Less likely to help
Patients with non-autoimmune related conditions or those without any inflammatory diseases may not benefit from this research.
What this research studies
This research investigates the interactions between immune cells and blood vessels, focusing on how blood vessels change during infections and inflammation. It aims to develop a new high-throughput assay that can accurately measure these interactions in a controlled environment, which includes the alignment of endothelial cells and their connections with immune cells. By improving our understanding of these processes, the research seeks to identify how vascular dysfunction contributes to autoimmune diseases and chronic inflammation.
Why it matters
Potential benefit: If successful, this research could lead to better treatments for autoimmune diseases by enhancing our understanding of immune cell behavior and blood vessel function.
How similar studies have gone: While the approach is innovative, similar research has shown promise in understanding immune interactions, indicating potential for success.
Where this research is happening
-
Cornell University
Ithaca, United States Active
Researchers
- Principal investigator: Lee, Esak — Cornell University
- Study coordinator: Lee, Esak
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.