Targeting thymidine phosphorylase to improve antiplatelet therapy
Official title: Thymidine Phosphorylase: a Novel Target of Antiplatelet Therapy
Funded at Marshall University · NIH-10448031 · Data updated 2026-11-12
This study is looking at how a specific enzyme called thymidine phosphorylase affects the way platelets in your blood activate and form clots, with the goal of finding safer treatments to prevent dangerous blood clots, especially for people at risk due to severe COVID-19.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Marshall University NIH-funded |
| Lab location | 1 site (Huntington, UNITED STATES) |
| Project start | January 3, 2019 |
| Project end | June 30, 2025 |
| Funding year | 2022 |
| Award (this year) | $444,000 |
| NIH project number | 2R15HL145573-02 |
| Project ID | NIH-10448031 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include patients with a history of cardiovascular disease, those at risk for thrombotic events, and individuals suffering from severe COVID-19.
✕Less likely to help
Patients who do not have issues related to blood clotting or those who are not at risk for thrombotic events may not benefit from this research.
What this research studies
This research investigates the role of thymidine phosphorylase (TYMP) in platelet activation, which is a key factor in blood clot formation that can lead to serious conditions like heart attacks and strokes. The study aims to develop new therapies that inhibit TYMP to prevent thrombosis without causing the side effects associated with current antiplatelet medications. By focusing on the molecular mechanisms of platelet activation, the research seeks to provide a safer alternative for patients at risk of thrombotic events, especially those affected by severe COVID-19.
Why it matters
Potential benefit: If successful, this research could lead to safer antiplatelet therapies that reduce the risk of thrombosis without significant side effects.
How similar studies have gone: Previous research has shown promise in targeting molecular mechanisms for antiplatelet therapy, but this specific approach focusing on TYMP is relatively novel.
Where this research is happening
-
Marshall University
Huntington, United States Active
Researchers
- Principal investigator: Li, Wei — Marshall University
- Study coordinator: Li, Wei
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.