Targeting specific proteins in brain tumors to improve immunotherapy
Proj. 1 Targeting Tumor-Specific Neoepitopes for Glioblastoma Immunotherapy
This study is testing a personalized vaccine designed to help your immune system fight glioblastoma, a type of brain cancer, by targeting specific proteins in your tumor, and it will also look at how well this vaccine works when combined with another treatment called anti-PD-1 therapy.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10876406 on NIH RePORTER |
What this research studies
This research focuses on developing a personalized vaccine that targets unique proteins found in glioblastoma tumors, which are the most common type of malignant brain cancer. By using advanced sequencing techniques, the researchers aim to identify these tumor-specific neoantigens and create a vaccine that stimulates the immune system to attack the cancer. The study will also explore the combination of this vaccine with anti-PD-1 therapy, which has shown promise in enhancing immune responses in other cancers. Patients will be monitored for immune responses and tumor changes as part of the trial.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with newly diagnosed glioblastoma who have not yet undergone treatment.
Not a fit: Patients with non-malignant brain tumors or those who have previously received extensive treatment for glioblastoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for glioblastoma, potentially improving survival rates and quality of life for patients.
How similar studies have performed: Previous research has shown success with similar neoantigen-targeting approaches in other cancers, indicating potential for this method in glioblastoma.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Reardon, David a — Brigham and Women's Hospital
- Study coordinator: Reardon, David a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.