Targeting specific aging cells to improve metabolic health
Targeting p21-positive Senescent Cells in vivo for Alleviating Metabolic and Physical Dysfunction
This study is looking at how certain aging cells in the body might make it harder for people to use insulin properly, which can lead to issues like type 2 diabetes, and by removing these cells in mice, researchers hope to find new ways to help improve insulin sensitivity and overall health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Connecticut Sch of Med/dnt NIH-funded |
| Lab location | 1 site (Farmington, United States) |
| Project ID | NIH-10805480 on NIH RePORTER |
What this research studies
This research investigates the role of p21-positive senescent cells in insulin resistance, a condition linked to obesity and aging. By using a specialized mouse model, researchers can selectively target and eliminate these cells to assess their impact on metabolic dysfunction. The study aims to understand how clearing these cells can improve insulin sensitivity and overall physical health. If successful, this approach could lead to new treatments for conditions like type 2 diabetes and related chronic diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing insulin resistance, particularly those who are obese or at risk for type 2 diabetes.
Not a fit: Patients who are not experiencing insulin resistance or those with conditions unrelated to metabolic dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide new therapeutic strategies to improve metabolic health and reduce the risk of diabetes and other age-related diseases.
How similar studies have performed: Previous research has shown promising results in targeting senescent cells for improving metabolic health, suggesting that this approach may be effective.
Where this research is happening
Farmington, United States
- University of Connecticut Sch of Med/dnt — Farmington, United States (Active)
Researchers
- Principal investigator: Xu, Ming — University of Connecticut Sch of Med/dnt
- Study coordinator: Xu, Ming
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.