Targeting RNA to control gene expression
Official title: Control of gene expression via RNA-targeted covalent probes
Funded at Univ of North Carolina Chapel Hill · NIH-11089312 · Data updated 2026-11-12
This study is exploring new tiny molecules that can attach to RNA in our cells, which could help us find new ways to control how genes work and develop better treatments for various health conditions.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project start | June 1, 2023 |
| Project end | May 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $84,364 |
| NIH project number | 5F32GM149162-03 |
| Project ID | NIH-11089312 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions that could benefit from targeted gene regulation, such as genetic disorders or cancers.
✕Less likely to help
Patients with conditions unrelated to RNA function or those who do not have a genetic component may not benefit from this research.
What this research studies
This research focuses on developing new small molecules that can specifically bind to RNA, which plays a crucial role in protein function and cellular processes. By using a novel technology that allows for high-throughput screening of RNA interactions, the researchers aim to identify sites on RNA that can be targeted for therapeutic purposes. The project will extend this technology to human cells, aiming to create covalent bonds with RNA at specific sites, potentially leading to new ways to regulate gene expression.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that precisely control gene expression, offering new treatment options for various diseases.
How similar studies have gone: While targeting RNA for therapeutic purposes is a relatively novel approach, preliminary studies have shown promise in related methodologies.
Where this research is happening
-
Univ of North Carolina Chapel Hill
Chapel Hill, United States Active
Researchers
- Principal investigator: Khitun, Alexandra — Univ of North Carolina Chapel Hill
- Study coordinator: Khitun, Alexandra
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.