Targeting Plk1, Pdcd4, and mTORC2 to Treat Castration-Resistant Prostate Cancer

Who could benefit from this research

What this research studies

This project looks at how specific proteins (Plk1, Pdcd4, and mTORC2) control prostate cancer cell growth and resistance to hormone therapies. Researchers plan to uncover how Pdcd4 is regulated and how Plk1 influences Pdcd4 to identify new targets for therapy. The work builds on prior findings that blocking Plk1 can boost the effectiveness of existing androgen-signaling inhibitors. The long-term goal is to develop treatment options for CRPC patients who no longer respond to standard ASIs. The study will use molecular and cellular approaches to map these signaling pathways and test potential interventions.

Why it matters

Where this research is happening

• University of Kentucky
  Lexington, United States Active

Researchers

• Principal investigator: Liu, Xiaoqi — University of Kentucky
• Study coordinator: Liu, Xiaoqi

Related research

Other NIH-funded projects on the same topics.

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• Enhancer RNA CYP11A1-eRNA in castration-resistant prostate cancer

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  NIH research University of Maryland Baltimore · Baltimore, United States · NIH-11452128

• Targeted Immunostimulatory Dual Drug Conjugates for Heterogeneous Metastatic Prostate Cancer

  Researchers are testing a targeted therapy approach to help people with metastatic castration-resistant prostate cancer by boosting the immune system and delivering drugs directly to cancer cells.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11427360

• Androgen Receptor Action in Prostate Cancer that Stops Responding to Therapy

  This grant supports research to understand why certain prostate cancers stop responding to AR-targeted therapies and to find new ways to target them.

  NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-11419184

• Hyperactive methylation in a hard-to-treat prostate cancer subtype

  Researchers are studying a newly identified methylation-heavy group of advanced prostate cancer to understand its biology and find clues for better treatments.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11415138

• Therapeutic Targeting of Lineage Plasticity in Advanced Prostate Cancer

  A cancer research effort aimed at understanding and tackling how aggressive prostate cancers become resistant to standard AR-targeted therapies.

  NIH research Sloan-Kettering Inst Can Research · New York, United States · NIH-11411377

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.