Targeting non-coding RNAs to treat heart disease in diabetes
Official title: Discovery and therapeutic targeting non-coding RNAs in T1D- or T2D-associated atherosclerosis
Funded at Brigham and Women's Hospital · NIH-11073136 · Data updated 2026-11-12
This study is looking at how certain molecules in the body affect heart health in people with type 1 and type 2 diabetes, with the goal of finding new ways to prevent or treat artery problems that can happen because of diabetes.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 18, 2024 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $1,022,611 |
| NIH project number | 1U01DK142281-01 |
| Project ID | NIH-11073136 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with type 1 or type 2 diabetes who are at risk for cardiovascular disease.
✕Less likely to help
Patients without diabetes or those who do not have cardiovascular risk factors may not benefit from this research.
What this research studies
This research investigates how non-coding RNAs contribute to the development of atherosclerosis in individuals with type 1 and type 2 diabetes. By understanding the molecular mechanisms involved, the study aims to identify new therapeutic targets that could help reduce cardiovascular risks associated with diabetes. The approach includes analyzing the inflammatory processes and cellular functions that lead to plaque buildup in blood vessels. Patients may benefit from novel treatments designed to prevent or reverse atherosclerosis linked to their diabetes.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly reduce the risk of cardiovascular disease in patients with diabetes.
How similar studies have gone: Previous research has shown promise in targeting non-coding RNAs for various diseases, suggesting potential success in this novel approach for diabetes-related atherosclerosis.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Feinberg, Mark W — Brigham and Women's Hospital
- Study coordinator: Feinberg, Mark W
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.