Targeting inflammation-resolving pathways to help with vascular brain aging
Official title: Targeting Inflammation-Resolution Pathways to Limit VCID
Funded at Albany Medical College · NIH-11366580 · Data updated 2026-11-12
Aimed at finding new ways to reduce vascular-driven brain changes that contribute to Alzheimer’s and related dementias by targeting how the body resolves inflammation.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albany Medical College NIH-funded |
| Lab location | 1 site (Albany, United States) |
| Project start | June 1, 2026 |
| Project end | May 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $1,951,689 |
| NIH project number | 1RF1NS140762-01A1 |
| Project ID | NIH-11366580 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with ADRD or vascular-related cognitive impairment who could participate in future trials or related studies.
✕Less likely to help
People without ADRD or vascular cognitive impairment may not benefit directly from this research.
What this research studies
This project looks at why inflammation doesn’t settle properly in the brain when blood vessels are affected, which raises dementia risk. Researchers will study how special molecules that normally help finish inflammation, called pro-resolving mediators, interact with brain immune cells in VCID and ADRD. The work will combine lab experiments and animal or cellular models to uncover new mechanisms and test potential ways to shift inflammation toward healing. If successful, the findings could point to new strategies to protect brain health in people with vascular risk factors and dementia. The study is led by Albany Medical College to explore translating these insights into therapies.
Why it matters
Potential benefit: If the approach succeeds, it could lead to new therapies that reduce brain damage from vascular issues and potentially slow ADRD progression.
How similar studies have gone: Previous work suggests targeting inflammation resolution can influence brain immune responses, but application to VCID/ADR D is still emerging.
Where this research is happening
-
Albany Medical College
Albany, United States Active
Researchers
- Principal investigator: Fredman, Gabrielle — Albany Medical College
- Study coordinator: Fredman, Gabrielle
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.