Targeting immune cells to reduce inflammation using bacterial proteins
Official title: Dendritic cell targeting by bacterial LysM proteins to suppress inflammation
Funded at University of Colorado Denver · NIH-10895432 · Data updated 2026-11-12
This study is looking at how specific proteins from bacteria can help control inflammation in the body by working with important immune cells, which could lead to new treatments for people with chronic inflammatory diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | August 1, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $463,755 |
| NIH project number | 5R01AI178925-02 |
| Project ID | NIH-10895432 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from chronic inflammatory conditions such as arthritis, atherosclerosis, or COPD.
✕Less likely to help
Patients with acute infections or those not experiencing chronic inflammation may not benefit from this research.
What this research studies
This research investigates how certain bacterial proteins can influence immune responses to manage inflammation. By focusing on dendritic cells, which play a crucial role in the immune system, the study aims to understand how these proteins can promote the production of anti-inflammatory cytokines like IL-10. The approach involves dissecting the mechanisms of action of these proteins and their interactions with immune receptors. Patients may benefit from insights that could lead to new treatments for chronic inflammatory diseases.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that effectively reduce chronic inflammation in various diseases.
How similar studies have gone: Previous research has shown promise in using bacterial proteins to modulate immune responses, indicating potential for success in this novel approach.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Lenz, Laurel L — University of Colorado Denver
- Study coordinator: Lenz, Laurel L
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.