Targeting HPV-related cancers with engineered T cells
Official title: E7 TCR-T cell therapy for HPV-associated cancers
Funded at Rutgers Biomedical and Health Sciences · NIH-10827717 · Data updated 2026-11-12
This study is testing a new treatment for HPV-related cancers, like cervical and anal cancers, by using your own immune cells to better fight the cancer while protecting healthy tissue, and it's aimed at helping patients with tough-to-treat cases.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project start | August 1, 2024 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $642,086 |
| NIH project number | 1U01CA287904-01 |
| Project ID | NIH-10827717 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with advanced-stage HPV-associated cancers who have not responded to standard treatments.
✕Less likely to help
Patients with non-HPV-associated cancers or those who are in early stages of HPV-related cancers may not benefit from this research.
What this research studies
This research focuses on developing a novel treatment for cancers associated with human papillomavirus (HPV), such as cervical and anal cancers. It utilizes a type of immunotherapy that involves engineering a patient's own T cells to specifically target and attack cancer cells expressing the HPV E7 protein. By using high-avidity T cells, the therapy aims to enhance the immune response against these tumors while minimizing damage to healthy tissues. The approach has shown promise in early clinical trials for patients with advanced-stage, treatment-resistant cancers.
Why it matters
Potential benefit: If successful, this research could provide a more effective and targeted treatment option for patients suffering from HPV-associated cancers.
How similar studies have gone: Similar approaches using engineered T cell therapies have shown success in other cancer types, indicating potential for this novel treatment in HPV-associated malignancies.
Where this research is happening
-
Rutgers Biomedical and Health Sciences
Newark, United States Active
Researchers
- Principal investigator: Hinrichs, Christian — Rutgers Biomedical and Health Sciences
- Study coordinator: Hinrichs, Christian
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.