Targeting factors that help the heart and lungs adapt to low oxygen levels
Targeting Hypoxia-Inducible Factors (HIFs) for Heart and Lung Disease
This study is looking at how certain proteins that help our bodies respond to low oxygen can be used to improve treatment for heart and lung diseases, especially during serious conditions like ARDS and heart attacks, so that patients can recover better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11037681 on NIH RePORTER |
What this research studies
This research investigates how hypoxia-inducible factors (HIFs) can be targeted to improve outcomes in heart and lung diseases, particularly during conditions like acute respiratory distress syndrome (ARDS) and myocardial ischemia. The study focuses on understanding how these factors are stabilized during low oxygen levels and inflammation, and how they can help reduce excessive tissue damage. By exploring the roles of different HIF isoforms and their specific functions in various tissues, the research aims to develop new therapeutic strategies that could enhance patient recovery. Patients may benefit from insights gained into how to better manage their conditions through targeted therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals suffering from acute respiratory distress syndrome or other related heart and lung conditions.
Not a fit: Patients with stable heart and lung conditions who do not experience acute episodes may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve recovery and outcomes for patients with heart and lung diseases.
How similar studies have performed: Previous research has shown promising results in targeting hypoxia-inducible factors for therapeutic purposes, indicating potential for success in this approach.
Where this research is happening
Houston, United States
- University of Texas Hlth Sci Ctr Houston — Houston, United States (Active)
Researchers
- Principal investigator: Eltzschig, Holger K. — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Eltzschig, Holger K.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.