Targeting cancer cell protein granules to improve treatment
Official title: Therapeutic targeting of RTK protein granules in cancer
Funded at Sloan-Kettering Inst Can Research · NIH-11087566 · Data updated 2026-11-12
This study is looking at how certain proteins in cancer cells form clusters that help the cancer grow, and it's working on new treatments that can target these clusters to help patients with advanced cancers who haven't responded to regular therapies.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | June 1, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $248,544 |
| NIH project number | 5K08CA270407-03 |
| Project ID | NIH-11087566 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults with advanced cancers driven by RTK fusion oncoproteins.
✕Less likely to help
Patients with early-stage cancers or those not driven by RTK fusion oncoproteins may not benefit from this research.
What this research studies
This research investigates how certain proteins in cancer cells, specifically RTK fusion oncoproteins, form granules that play a crucial role in cancer progression. The project aims to develop new therapies that specifically target these granules to disrupt their function and improve treatment outcomes for patients with advanced cancers. The approach includes using mouse models and advanced microscopy techniques to study these protein structures and their effects on cancer signaling. By understanding the biology behind these granules, the research seeks to create more effective treatments for patients who have become resistant to standard therapies.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly improve treatment options for patients with advanced cancer.
How similar studies have gone: Other research has shown promise in targeting similar oncogenic signaling pathways, indicating potential for success in this approach.
Where this research is happening
-
Sloan-Kettering Inst Can Research
New York, United States Active
Researchers
- Principal investigator: Tulpule, Asmin — Sloan-Kettering Inst Can Research
- Study coordinator: Tulpule, Asmin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.