Targeting a specific signaling pathway in prostate cancer
Official title: Upstream and downstream targeting of the SPOP ubiquitin signaling pathway in prostate cancer
Funded at Weill Medical Coll of Cornell Univ · NIH-10999747 · Data updated 2026-11-12
This study is looking at how certain changes in the SPOP gene affect prostate cancer and how these changes might influence treatment options, with the goal of finding better therapies for patients with this specific type of cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $710,980 |
| NIH project number | 1R01CA287724-01A1 |
| Project ID | NIH-10999747 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with prostate cancer, particularly those with SPOP mutations.
✕Less likely to help
Patients with prostate cancer who do not have SPOP mutations may not benefit from this research.
What this research studies
This research investigates the SPOP ubiquitin signaling pathway in prostate cancer, focusing on a specific subclass of the disease characterized by mutations in the SPOP gene. By examining how these mutations affect cancer biology and treatment responses, the research aims to identify novel therapeutic strategies. The team will utilize advanced models and human samples to explore the role of G3BP1, an upstream regulator of SPOP, in influencing cancer progression and treatment outcomes. This approach seeks to enhance our understanding of prostate cancer and improve targeted therapies for affected patients.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients with specific prostate cancer mutations.
How similar studies have gone: Previous research has shown promising results in targeting similar signaling pathways in cancer treatment, suggesting potential for success in this approach.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Zhou, Pengbo — Weill Medical Coll of Cornell Univ
- Study coordinator: Zhou, Pengbo
Related research
Other NIH-funded projects on the same topics.
-
Cardiovascular risk planning and reduction for men with prostate cancer
A program to better predict and reduce heart disease risk in men treated for prostate cancer, especially older patients.
-
Effects of ADT on motivation and emotion in prostate cancer patients
This project looks at how androgen deprivation therapy may affect motivation and mood over time in men with prostate cancer.
-
Causal Protein Markers to Understand and Predict Prostate Cancer Risk in Africans and Europeans
A cancer research project looking at proteins linked to prostate cancer to better understand why it happens and how risk differs between African and European populations.
-
Ethical multimodal AI platform to improve prostate cancer detection with ultrasound
A patient-friendly AI system uses ultrasound and MRI information to help doctors better find prostate cancer, aiming to improve accuracy and access.
-
Characterizing epigenetic targets in prostate cancer to help AR-driven cancer
A research project at MD Anderson aims to understand how epigenetic factors shape androgen receptor signaling in prostate cancer to find new ways to treat resistant forms of the disease.
-
AR and RNA-binding in prostate cancer resistance
A cancer research grant exploring how the androgen receptor’s interaction with RNA may drive treatment resistance in prostate cancer, with potential to guide new therapies.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.