Targeting a specific signaling pathway in prostate cancer
Upstream and downstream targeting of the SPOP ubiquitin signaling pathway in prostate cancer
This study is looking at how certain changes in the SPOP gene affect prostate cancer and how these changes might influence treatment options, with the goal of finding better therapies for patients with this specific type of cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10999747 on NIH RePORTER |
What this research studies
This research investigates the SPOP ubiquitin signaling pathway in prostate cancer, focusing on a specific subclass of the disease characterized by mutations in the SPOP gene. By examining how these mutations affect cancer biology and treatment responses, the research aims to identify novel therapeutic strategies. The team will utilize advanced models and human samples to explore the role of G3BP1, an upstream regulator of SPOP, in influencing cancer progression and treatment outcomes. This approach seeks to enhance our understanding of prostate cancer and improve targeted therapies for affected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with prostate cancer, particularly those with SPOP mutations.
Not a fit: Patients with prostate cancer who do not have SPOP mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients with specific prostate cancer mutations.
How similar studies have performed: Previous research has shown promising results in targeting similar signaling pathways in cancer treatment, suggesting potential for success in this approach.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Zhou, Pengbo — Weill Medical Coll of Cornell Univ
- Study coordinator: Zhou, Pengbo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.