Targeted treatment for acute lung injury using isolated lung perfusion
Official title: Targeted treatment of acute lung injury using isolated lung perfusion
Funded at University of Virginia · NIH-11001232 · Data updated 2026-11-12
This study is exploring a new way to help people with serious lung injuries, like ARDS, by delivering treatments directly to the lungs while minimizing effects on the rest of the body, which could lead to better recovery and improved lung function.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project start | December 20, 2023 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $725,955 |
| NIH project number | 5R01HL168041-02 |
| Project ID | NIH-11001232 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults suffering from acute respiratory distress syndrome or those who have experienced lung injury due to sepsis or lung transplantation.
✕Less likely to help
Patients with chronic lung diseases or those who do not have acute lung injury may not benefit from this research.
What this research studies
This research investigates a novel approach to treat acute lung injury, particularly acute respiratory distress syndrome (ARDS), by using isolated lung perfusion techniques. The study aims to rehabilitate injured lungs through a method that allows for targeted therapies to be administered directly to the lungs without affecting the rest of the body. By utilizing a specialized solution called Steen solution, the research seeks to improve lung function and reduce damage caused by conditions like sepsis and ischemia-reperfusion injury. Patients may benefit from this innovative treatment approach that could lead to better outcomes compared to current supportive care methods.
Why it matters
Potential benefit: If successful, this research could provide a targeted treatment option that significantly improves recovery and outcomes for patients with acute lung injury.
How similar studies have gone: Previous research has shown promising results with isolated lung perfusion techniques, indicating potential for success in this novel approach.
Where this research is happening
-
University of Virginia
Charlottesville, United States Active
Researchers
- Principal investigator: Kron, Irving L. — University of Virginia
- Study coordinator: Kron, Irving L.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.