Synthetic chemistry and biology tools to study proteins and modify their function
Official title: Developing synthetic chemical biology strategies for biochemical investigations and biomedical applications
Funded at University of Nebraska Lincoln · NIH-11357633 · Data updated 2026-11-12
New ways to modify proteins and study how they work could lead to better therapies, using lab-made amino acids and genetic code tricks.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Lincoln NIH-funded |
| Lab location | 1 site (Lincoln, United States) |
| Project start | July 15, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $369,590 |
| NIH project number | 5R35GM149322-04 |
| Project ID | NIH-11357633 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable to patient participation directly in this grant.
✕Less likely to help
No direct patient participation or immediate benefits for patients in this grant.
What this research studies
This grant explores how to precisely modify proteins during production and function using noncanonical amino acids and reprogrammed genetic code. Researchers will test quadruplet codons and recoding signals to improve how and when protein changes occur. The work aims to create powerful tools that can help understand disease-related protein behavior and guide future therapies. The focus is on developing strategies that can be used across biological systems to reveal how proteins contribute to health and disease.
Why it matters
Potential benefit: If successful, this work could provide novel chemical biology tools to uncover disease mechanisms and support new therapeutic strategies.
How similar studies have gone: Previous work on noncanonical amino acids and genetic code engineering has shown promising results in protein science, with growing potential for biomedical applications.
Where this research is happening
-
University of Nebraska Lincoln
Lincoln, United States Active
Researchers
- Principal investigator: Guo, Jiantao — University of Nebraska Lincoln
- Study coordinator: Guo, Jiantao
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.