Synthesis of partially saturated nitrogen rings through selective dearomatization of heteroarenes
Official title: Synthesis of Partially Saturated Nitrogen Heterocycles Through Stereo- And Regioselective Dearomatization of Heteroarenes
Funded at Auburn University at Auburn · NIH-11345567 · Data updated 2026-11-12
A new chemical method aims to make partially saturated nitrogen-containing rings more efficiently, which could benefit drug, crop, and material science applications.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Auburn University at Auburn NIH-funded |
| Lab location | 1 site (Auburn, UNITED STATES) |
| Project start | August 15, 2022 |
| Project end | June 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $373,742 |
| NIH project number | 5R35GM147244-05 |
| Project ID | NIH-11345567 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not directly patient-facing; basic chemical research with potential downstream benefits for medicines and agrochemicals.
✕Less likely to help
The work does not involve directly studying or recruiting patients.
What this research studies
This project focuses on developing new chemical transformations that add functional groups to heteroarenes in a controlled, stereoselective way to create six-membered nitrogen rings. The work explores regioselective and stereoselective dearomatization and catalytic addition of nucleophiles and electrophiles to heteroarenes. By improving access to partially saturated azaheterocycles, the research could streamline synthesis of compounds used in medicines, pesticides, and materials. The long-term goal is to provide versatile building blocks that can be converted into both aromatic and non-aromatic nitrogen heterocycles.
Why it matters
Potential benefit: If successful, patients could benefit indirectly from more efficient production of pharmaceuticals and agrochemicals.
How similar studies have gone: There is ongoing progress in heteroarene chemistry, but selective dearomatization with precise stereocontrol remains a developing area.
Where this research is happening
-
Auburn University at Auburn
Auburn, United States Active
Researchers
- Principal investigator: Karimov, Rashad Rishad — Auburn University at Auburn
- Study coordinator: Karimov, Rashad Rishad
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.