Study of C5aR receptors in mice to understand immune signaling
Official title: Generation of C5aR-TurboID mice
Funded at Boston University Medical Campus · NIH-11446318 · Data updated 2026-11-12
A small grant will create a special mouse line to study how C5a receptors control immune responses in inflammation.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 1, 2026 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $81,750 |
| NIH project number | 1R03AI203321-01 |
| Project ID | NIH-11446318 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals with inflammatory or immune-mediated conditions in which C5a signaling is relevant, to inform future patient-focused studies.
✕Less likely to help
No direct patient benefit is expected from this mouse-focused research at this stage.
What this research studies
This project will generate mice engineered to study the C5a receptor pathways, focusing on how C5aR1 and C5aR2 influence immune cell behavior and signaling. Researchers will use these mice to map signaling events and interactions in tissues affected by inflammation, using basic biological assays and biotinylation to track receptor activity. The work aims to clarify how these receptors contribute to lung inflammation and tissue injury, which could inform future therapies for inflammatory diseases.
Why it matters
Potential benefit: Understanding C5a receptor signaling could lead to new approaches to treat inflammatory diseases and reduce tissue damage.
How similar studies have gone: Previous studies showing that altering C5a receptor signaling affected inflammation provide a basis for optimism in similar approaches.
Where this research is happening
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Boston University Medical Campus
Boston, United States Active
Researchers
- Principal investigator: Bosmann, Markus — Boston University Medical Campus
- Study coordinator: Bosmann, Markus
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.