Spatio-temporal regulation of neutrophil behavior in the lungs during acute injury
Official title: Spatio-temporal regulation of pulmonary neutrophil plasticity
Funded at Louisiana State Univ Hsc Shreveport · NIH-11518279 · Data updated 2026-11-12
Researchers are studying how immune cells in the lungs change shape and behavior during acute lung injury to understand why some responses help fight infection and others cause damage.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Louisiana State Univ Hsc Shreveport NIH-funded |
| Lab location | 1 site (Shreveport, United States) |
| Project start | June 1, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $365,000 |
| NIH project number | 7R01AI182185-03 |
| Project ID | NIH-11518279 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are patients with acute lung injury or ARDS who participate in related future studies or contribute samples; however, this grant itself is preclinical and primarily uses animal imaging models.
✕Less likely to help
Patients without ARDS or acute lung injury may not directly benefit from this preclinical work.
What this research studies
This grant supports work in mice to map how neutrophils adapt their movement and function in the lungs when injury occurs. The team has built an advanced imaging system to watch neutrophils in living lungs and measure their activity in real time. By tracking these cells’ nuclei loss, shape changes, and calcium and mitochondrial signals, the study aims to reveal how the lung environment affects immune responses during ARDS and related conditions. The goal is to identify mechanisms that could be targeted to improve outcomes in patients with acute pulmonary injury.
Why it matters
Potential benefit: Better understanding of neutrophil behavior could lead to new strategies to reduce lung damage and improve recovery in ARDS and similar conditions.
How similar studies have gone: Previous studies using high-resolution lung imaging have shown neutrophil dynamics can influence injury outcomes, supporting further exploration of this approach.
Where this research is happening
-
Louisiana State Univ Hsc Shreveport
Shreveport, United States Active
Researchers
- Principal investigator: Tsukasaki, Yoshikazu — Louisiana State Univ Hsc Shreveport
- Study coordinator: Tsukasaki, Yoshikazu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.