Spatially resolved single-cell multiomics for healthier futures
Official title: Pioneering assays for spatially-resolved single-cell multiomics
Funded at Survey Genomics, INC. · NIH-11303371 · Data updated 2026-11-12
A new tool called Cytope-drop helps scientists map where individual cells sit in relation to each other while reading their molecular messages, which could lead to better understanding and treatment of autoimmune and other diseases.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Survey Genomics, INC. NIH-funded |
| Lab location | 1 site (Berkeley, United States) |
| Project start | September 19, 2024 |
| Project end | February 28, 2027 |
| Funding year | 2026 |
| Award (this year) | $876,466 |
| NIH project number | 5R44HG013294-03 |
| Project ID | NIH-11303371 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not a patient-recruiting study; however, results could ultimately benefit patients by improving understanding of diseases that involve immune cells and tissue organization.
✕Less likely to help
No direct patient participation is required for this grant.
What this research studies
This project aims to advance a technology that links what each cell is saying with where it sits in tissue, using 50-um spatial resolution and compatibility with FFPE samples. It builds on Cytope-drop, a drop-based method that adds spatial context to single-cell multiomics without new major equipment. The work includes scaling up manufacturing and ensuring the method works with preserved tissue, so researchers can study patient samples more easily. Together, these improvements could accelerate discovery of how cellular neighborhoods contribute to disease and to identifying new therapeutic targets.
Why it matters
Potential benefit: If successful, researchers could map disease-related cellular interactions more accurately, speeding development of targeted therapies.
How similar studies have gone: Precedents exist for spatial single-cell methods showing promise, with growing adoption in research settings.
Where this research is happening
-
Survey Genomics, INC.
Berkeley, United States Active
Researchers
- Principal investigator: Hartoularos, George Christopher — Survey Genomics, INC.
- Study coordinator: Hartoularos, George Christopher
Related research
Other NIH-funded projects on the same topics.
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Innovative methods for analyzing individual cells in their spatial context
This study is exploring how cells talk to each other and their surroundings, which is important for figuring out how diseases develop, and it uses a new method to look closely at individual cells and their neighbors to find new ways to treat these conditions.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.