Innovative methods for analyzing individual cells in their spatial context
Official title: Pioneering assays for spatially-resolved single-cell multiomics
Funded at Survey Genomics, INC. · NIH-11241688 · Data updated 2026-11-12
This study is exploring how cells talk to each other and their surroundings, which is important for figuring out how diseases develop, and it uses a new method to look closely at individual cells and their neighbors to find new ways to treat these conditions.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Survey Genomics, INC. NIH-funded |
| Lab location | 1 site (Berkeley, United States) |
| Project start | September 19, 2024 |
| Project end | February 28, 2027 |
| Funding year | 2025 |
| Award (this year) | $1,091,941 |
| NIH project number | 4R44HG013294-02 |
| Project ID | NIH-11241688 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with advanced diseases or conditions that involve complex cellular interactions, such as cancers or autoimmune disorders.
✕Less likely to help
Patients with isolated or non-complex conditions that do not involve significant cellular communication issues may not benefit from this research.
What this research studies
This research focuses on understanding how cells interact and communicate within their environment, which is crucial for uncovering the mechanisms behind various diseases. By using a novel technique called Cytope-drop, researchers can analyze individual cells while also capturing their spatial relationships with neighboring cells. This approach allows for high-throughput analysis of multiple cellular features, such as gene expression and protein presence, without needing extra equipment. The goal is to enhance our understanding of disease progression and potentially identify new therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in diagnosing and treating diseases by providing deeper insights into cellular interactions and dysfunctions.
How similar studies have gone: Other research has shown promise in using spatially-resolved single-cell analysis techniques, indicating that this approach could lead to significant advancements in understanding disease mechanisms.
Where this research is happening
-
Survey Genomics, INC.
Berkeley, United States Active
Researchers
- Principal investigator: Pham, Lin — Survey Genomics, INC.
- Study coordinator: Pham, Lin
Related research
Other NIH-funded projects on the same topics.
-
Spatially resolved single-cell multiomics for healthier futures
A new tool called Cytope-drop helps scientists map where individual cells sit in relation to each other while reading their molecular messages, which could lead to better understanding and treatment of autoimmune and other diseases.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.