Skeletal stem cell and immune cell dynamics in BMP-2 assisted cleft palate repair
Official title: Skeletal Stem Cell-Neutrophil Dynamics in Surrogate BMP-2 Cleft Palate Repair
Funded at University of Michigan at Ann Arbor · NIH-11621100 · Data updated 2026-11-12
A study explores how bone-building stem cells and immune cells interact to improve bone repair in cleft palate patients using BMP-2, aiming for a less invasive option than bone grafts.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | August 1, 2026 |
| Project end | July 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $249,000 |
| NIH project number | 4R00DE032773-03 |
| Project ID | NIH-11621100 on NIH RePORTER |
Who could benefit from this research
✓Could help
Candidates would be patients with cleft lip and palate considering BMP-2–based bone repair strategies.
✕Less likely to help
Patients not undergoing BMP-2–based repair or without access to related clinical settings may not directly benefit.
What this research studies
This project looks at why BMP-2 works differently in palatal bone compared to jawbone and how skeletal stem cells coordinate with immune cells during bone regeneration. Researchers will study cell behavior and signaling pathways in a model relevant to cleft palate repair to understand how BMP-2 promotes bone growth in the palate. The goal is to identify mechanisms that could boost effectiveness and reduce inflammation, guiding safer, patient-friendly treatments.
Why it matters
Potential benefit: If successful, the work could lead to more reliable, less invasive bone repair for babies with cleft palate.
How similar studies have gone: Prior studies show BMP-2 can aid bone repair but with variable palatal efficacy and inflammatory responses, highlighting the need for mechanism-driven improvements.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Takematsu, Eri — University of Michigan at Ann Arbor
- Study coordinator: Takematsu, Eri
Related research
Other NIH-funded projects on the same topics.
-
Expanding genetic testing for cancer risk in patients and families
This study is working to make it easier for cancer patients in Michigan to get genetic testing for cancer risk by improving how doctors gather family history and assess genetic risks, so that more people can receive the important evaluations they need.
-
HEARTS hypertension and diabetes care in Guatemala
This grant tests how well the HEARTS primary care model works in Guatemala to improve blood pressure and blood sugar control for patients.
-
Why the retina can sometimes heal itself and how we might help it heal
This NIH grant explores how inflammation and neural cells interact in the zebrafish retina to understand retinal neuron death and regeneration, with potential implications for human vision.
-
Integrated Heart Health: A HEARTS-based approach to hypertension and diabetes in Guatemala
A study tests a team-based, stepwise care model to improve blood pressure and blood sugar control for people with both hypertension and diabetes in Guatemala.
-
Understanding how work exposures and genes influence ALS risk
A study is building a long-term group of people at higher risk for ALS to see how their jobs, exposures at work, and genes together affect if and when the disease might develop.
-
An integrated mobile health program to reduce SAVA and mental health problems among female sex workers in Kenya
A new mobile health program aims to help female sex workers in Kenya avoid substance abuse, violence, HIV, and depression by delivering group therapy, online resources, and a peer discussion space.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.