Skeletal MyBP-C Regulation and Structure in Arthrogryposis
Official title: Skeletal Myosin-Binding Protein C Regulation and Structural Dynamics
Funded at University of Arizona · NIH-11548179 · Data updated 2026-11-12
A new project at the University of Arizona looks at how a muscle protein called MyBP-C controls muscle contraction and how its changes might cause arthrogryposis, with the goal of guiding future treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arizona NIH-funded |
| Lab location | 1 site (Tucson, United States) |
| Project start | July 15, 2022 |
| Project end | May 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $69,778 |
| NIH project number | 3R01AR079435-05S1 |
| Project ID | NIH-11548179 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with distal arthrogryposis or related skeletal muscle myopathy could be relevant for future translational research.
✕Less likely to help
This basic science project does not involve patient recruitment or direct treatment and may not provide immediate benefits to patients.
What this research studies
This project focuses on skeletal muscle proteins that regulate how muscles contract. Researchers have developed fluorescent sensors to watch how MyBP-C behaves when it’s phosphorylated or mutated, and how it interacts with actomyosin during force development. The work uses innovative biophysical tools to study structural dynamics in muscle fibers and aims to link these dynamics to the arthrogryposis condition. By understanding these molecular mechanisms, the team hopes to identify targets for potential therapies in the future.
Why it matters
Potential benefit: Better understanding of the molecular causes of arthrogryposis could guide the development of targeted therapies to improve muscle function.
How similar studies have gone: Previous work shows that studying MyBP-C phosphorylation and interactions can reveal mechanisms of muscle regulation, with potential translational implications.
Where this research is happening
-
University of Arizona
Tucson, United States Active
Researchers
- Principal investigator: Colson, Brett a — University of Arizona
- Study coordinator: Colson, Brett a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.