Selenium Metabolism and Selenoprotein Formation and Its Link to Alzheimer’s Disease
Official title: Regulation of Selenium Metabolism and Selenoprotein Synthesis
Funded at H. Lee Moffitt Cancer Ctr & Res Inst · NIH-11428062 · Data updated 2026-11-12
Researchers are studying how selenium is processed in the body and how selenoproteins are made, to understand potential connections to Alzheimer’s disease and dementia.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | H. Lee Moffitt Cancer Ctr & Res Inst NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project start | September 1, 2026 |
| Project end | May 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $421,250 |
| NIH project number | 1R35GM165628-01 |
| Project ID | NIH-11428062 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with Alzheimer’s disease or dementia, or those at risk for neurodegenerative conditions, who could participate in future translation of selenium-based strategies.
✕Less likely to help
There may be no direct benefit for individuals without neurodegenerative conditions or when selenium forms or delivery methods are not advantageous.
What this research studies
This research will explore how different forms of selenium are absorbed and distributed in the body and how tissues regulate the production of selenoproteins under stress. Using animal models and functional genomic approaches, the project aims to uncover how selenium metabolism impacts redox balance, cell protection, and disease processes related to Alzheimer’s disease. The findings could illuminate why selenium supplementation helps some people but not others, and what forms or delivery methods might be more effective. The work is designed to translate basic biology into potential strategies for improving brain health in disorders linked to oxidative stress.
Why it matters
Potential benefit: It could lead to more precise dietary or therapeutic approaches that support brain health in people at risk for or living with Alzheimer’s disease.
How similar studies have gone: Previous research suggests selenium metabolism and selenoprotein production influence oxidative stress, but results on dementia outcomes have been inconclusive, making this both continuing and potentially transformative.
Where this research is happening
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H. Lee Moffitt Cancer Ctr & Res Inst
Tampa, United States Active
Researchers
- Principal investigator: Jiang, Chang — H. Lee Moffitt Cancer Ctr & Res Inst
- Study coordinator: Jiang, Chang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.