Role of B-Arrestin Signaling in Brain Angiotensin Receptor Pathways
Official title: Project 1: Role and Mechanisms of B-Arrestin Signaling Downstream of Ang-II AT1 Receptor in the Brain
Funded at Medical College of Wisconsin · NIH-11420076 · Data updated 2026-11-12
A large, multi-year project will explore how a specific signaling pathway (beta-arrestin) at brain angiotensin receptors affects fluid balance and blood pressure in order to improve understanding of brain regulation of cardiometabolic health.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project start | September 1, 2026 |
| Project end | June 30, 2031 |
| Funding year | 2026 |
| Award (this year) | $643,879 |
| NIH project number | 1P01HL180287-01A1 |
| Project ID | NIH-11420076 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates would be individuals with cardiovascular or metabolic conditions that could benefit from future translational insights into brain regulation of BP and fluid balance.
✕Less likely to help
Healthy individuals or those without interest in brain mechanisms of BP regulation may not directly benefit from this basic science study.
What this research studies
This project investigates how beta-arrestin signaling at AT1 receptors in the brain contributes to control of fluid intake and blood pressure. By studying neural circuits and signaling mechanisms, researchers aim to distinguish beta-arrestin–driven effects from traditional G-protein signals. The work uses animal models to parse how these pathways influence salt intake, sympathetic activity, and hypertension. Outcomes could illuminate new targets for treating high blood pressure and related metabolic conditions. The study spans several years and is led by the Medical College of Wisconsin team under a P01 grant umbrella.
Why it matters
Potential benefit: If successful, the research could lead to new approaches for managing blood pressure and fluid balance through brain signaling pathways.
How similar studies have gone: Previous work has shown that beta-arrestin pathways can have distinct effects from G-protein signaling, supporting potential relevance to human health.
Where this research is happening
-
Medical College of Wisconsin
Milwaukee, United States Active
Researchers
- Principal investigator: Sigmund, Curt Daniel — Medical College of Wisconsin
- Study coordinator: Sigmund, Curt Daniel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.